Compounded Semaglutide

Overview

What is Semaglutide?

Compounded semaglutide is a GLP-1 receptor agonist that mimics the body's natural glucagon-like peptide-1 hormone. Originally developed for Type 2 diabetes, semaglutide has become a first-line treatment for chronic weight management — with clinical trials demonstrating average weight loss of 15% body weight over 68 weeks.

Mechanism of action

How it works

Semaglutide works by activating GLP-1 receptors in the brain, which regulates appetite and reduces feelings of hunger. It also slows gastric emptying so you feel fuller for longer, and modulates the reward pathways associated with food intake. Together, these effects create a significant reduction in caloric intake without the need for willpower or restrictive diets.

Safety information

Potential side effects

• Nausea (most common, especially at dose initiation)
• Vomiting
• Diarrhea or constipation
• Reduced appetite
• Fatigue
• Injection site reactions (redness, swelling)
• Rare: pancreatitis, gallbladder disease

Who should not use this

Contraindications

• Personal or family history of medullary thyroid carcinoma (MTC)
• Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
• Pregnancy or breastfeeding
• Hypersensitivity to semaglutide or any component
• History of serious hypersensitivity reactions to GLP-1 agents